Cynthia L Sears Selected Research

Bacteroides fragilis toxin

1/2022	Label-Free Vibrational and Quantitative Phase Microscopy Reveals Remarkable Pathogen-Induced Morphomolecular Divergence in Tumor-Derived Cells.
1/2019	Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin.
1/2019	Epigenetic Changes Induced by Bacteroides fragilis Toxin.
2/2018	Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
1/2015	The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients.

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Cynthia L Sears Research Topics

Disease

31	Neoplasms (Cancer) 11/2022 - 09/2009
18	Colorectal Neoplasms (Colorectal Cancer) 11/2022 - 01/2015
11	Carcinogenesis 02/2022 - 09/2011
11	Inflammation (Inflammations) 01/2021 - 09/2008
7	Colitis 10/2019 - 12/2006
5	Infections 01/2022 - 07/2002
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021 - 01/2015
4	Colonic Neoplasms (Colon Cancer) 01/2020 - 01/2016
3	Bacterial Infections (Bacterial Infection) 01/2022 - 10/2015
3	Dysbiosis 01/2020 - 11/2019
3	Cryptosporidiosis 03/2007 - 07/2002
2	Crohn Disease (Crohn's Disease) 01/2022 - 01/2019
2	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2021
2	Polyps 12/2021 - 01/2020
2	Weight Loss (Weight Reduction) 01/2020 - 10/2019
2	Clostridium Infections 10/2019 - 10/2019
2	Microsatellite Instability 10/2019 - 11/2017
1	Neoplastic Cell Transformation 01/2022
1	Dermatomyositis (Dermatopolymyositis) 01/2022
1	Chronic Disease (Chronic Diseases) 01/2020
1	Insulin Resistance 01/2020
1	Obesity 01/2020
1	Short Bowel Syndrome 01/2020
1	Adenomatous Polyps 01/2020
1	Rectal Neoplasms (Rectal Cancer) 11/2019
1	Type 2 Diabetes Mellitus (MODY) 10/2019
1	Gallstones (Gallstone) 01/2019
1	Constipation 01/2019
1	Cerebrotendinous Xanthomatosis 01/2019
1	HIV Infections (HIV Infection) 01/2018
1	Atherosclerosis 01/2018
1	Carotid Artery Diseases 01/2018
1	Coronary Stenosis (Coronary Artery Stenosis) 05/2016
1	Adenoma (Adenomas) 12/2014

Drug/Important Bio-Agent (IBA)

9	Anti-Bacterial Agents (Antibiotics)IBA 11/2022 - 09/2004
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2017
5	CytokinesIBA 02/2022 - 07/2002
5	Bacteroides fragilis toxinIBA 01/2022 - 01/2015
5	16S Ribosomal RNAIBA 01/2020 - 01/2017
5	Interleukin-17 (Interleukin 17)IBA 12/2018 - 09/2009
4	DNA (Deoxyribonucleic Acid)IBA 10/2022 - 01/2017
3	Immune Checkpoint InhibitorsIBA 10/2022 - 01/2021
3	PolyaminesIBA 01/2016 - 09/2011
2	MutagensIBA 01/2022 - 01/2021
2	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2017
2	Calcibiotic Root Canal SealerIBA 12/2021 - 12/2014
2	Virulence Factors (Pathogenicity Factors)IBA 01/2021 - 10/2014
2	Interleukin-10 (Interleukin 10)IBA 01/2020 - 11/2019
2	Bile Acids and Salts (Bile Acids)IBA 01/2020 - 01/2019
2	ChromatinIBA 01/2019 - 01/2017
2	trimethyloxamine (trimethylamine N-oxide)IBA 01/2018 - 05/2016
1	FlagellinIBA 01/2022
1	AntibodiesIBA 01/2022
1	Type III Secretion SystemsIBA 01/2022
1	salicylhydroxamic acid (SHAM)IBA 01/2022
1	Biological ProductsIBA 01/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021
1	CateninsIBA 01/2021
1	Cadherins (E-Cadherin)IBA 12/2020
1	MicroRNAs (MicroRNA)IBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	Messenger RNA (mRNA)IBA 01/2020
1	EnzymesIBA 01/2020
1	N-(3,4,5-trichlorophenyl)succinimideIBA 01/2020
1	Lipocalin-2IBA 01/2020
1	CarbohydratesIBA 01/2020
1	Penicillins (Penicillin)FDA Link 11/2019
1	TetracyclinesIBA 11/2019
1	Amoxicillin (Wymox)FDA LinkGeneric 11/2019
1	Ampicillin (Omnipen)FDA LinkGeneric 11/2019
1	pembrolizumabIBA 10/2019
1	MucinsIBA 10/2019
1	Dihydrotachysterol (AT 10)IBA 10/2019
1	Interferon-gamma (Interferon, gamma)IBA 01/2019
1	fragilysinIBA 01/2019
1	MetalsIBA 01/2019
1	Metalloproteases (Metalloproteinases)IBA 01/2019
1	Pharmaceutical PreparationsIBA 01/2019
1	Polysaccharides (Glycans)IBA 01/2019
1	Chenodeoxycholic Acid (Chenix)FDA Link 01/2019
1	CXC ChemokinesIBA 02/2018
1	Choline (Choline Chloride)IBA 01/2018
1	Lipopolysaccharide ReceptorsIBA 01/2018
1	Immunologic Factors (Immunomodulators)IBA 11/2017
1	MutS ProteinsIBA 01/2017
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 05/2016
1	Cefoxitin (Cefoxitin Sodium)FDA LinkGeneric 01/2016
1	Interleukin-2 (IL2)IBA 10/2015
1	Transcription Factors (Transcription Factor)IBA 01/2015
1	Interleukin-17 ReceptorsIBA 05/2014
1	MDL 72527IBA 09/2011

Therapy/Procedure

9	Therapeutics 01/2022 - 02/2006
6	Immunotherapy 01/2021 - 11/2017
3	Fecal Microbiota Transplantation 10/2022 - 01/2019
1	Transplantation 10/2019
1	Bariatric Surgery 10/2019
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 10/2019
1	Drug Therapy (Chemotherapy) 01/2017
1	Lasers (Laser) 01/2015
1	Chemoprevention 09/2011